Dr. Jayanth Kumar, Associate Professor
(From left to right: Harsh, Jayanth, Sharath, Sumedha, Gunjan, Kriti, Ruchi)
Address: Room No. 4008, Convergence Block, AIIMS, New Delhi.
MBBS, Medicine and Surgery, August 2000-March 2006,
Government Stanley Medical College,
MD, Biochemistry, January 2007-January 2010,
All India Institute of Medical Sciences (AIIMS), New Delhi.
January 2010-April 2012
Senior Demonstrator, Biochemistry
All India Institute of Medical Sciences (AIIMS), New Delhi
May 2012-November 2014
Postdoctoral Research Fellowship
David Geffen School of Medicine at UCLA
Los Angeles, California
November 2014 – June 2017
Department of Biochemistry, AIIMS, New Delhi
Department of Biochemistry, AIIMS, New Delhi
Research Focus of the Lab
B-cell acute lymphoblastic leukemia/lymphoma (ALL) is a disease of the pediatric age group and is a major health problem worldwide. 50% of B-ALL tumors exhibit chromosomal rearrangements with ETV6-RUNX1 being the commonest.RNA binding proteins (RBPs) regulate gene expression post-transcriptionally. Our study identified an RBP IGF2BP1 (Insulin like Growth Factor 2 mRNA Binding Protein 1) to be highly expressed in B-ALL with ETV6-RUNX1 translocations. IGF2BP1 has previously been implicated in multiple epithelial tumors. Our knowledge about the linkage behind ETV6-RUNX1 translocation and RBP IGF2BP1 overexpression is deficient. Hence, we are attempting to answer the following research questions: Does IGF2BP1 expression correlate with disease progression? Does it synergize with ETV6-RUNX1 to cause leukemia? Being an RNA binding protein what are its direct targets in B-ALL? Can IGF2BP1 knockdown be a viable option to treat B-ALL? Our project hopes to define the clinical significance of IGF2BP1 in B-ALL, establish the RNA binding footprint for this protein and describe its mechanism of action in malignant transformation.
1. Graduate Students
Gunjan is a final year PhD student and DBT-SRF. She joined in August 2016. Her work focuses on elucidating the role of IGF2BP1 in ETV6-RUNX1 translocation positive pediatric patients. She uses a combination of molecular biology techniques and in-vivo/in-vitro experiments to elucidate the same.
Sumedha is a 4th year PhD student and ICMR-SRF. She joined the lab in March 2018. She is currently investigating the role of epitranscriptome and IGF2BP family of RNA-Binding Proteins in B-cell Acute Lymphoblastic Leukemia. She has a Masters in Biochemistry from AIIMS with a thesis focussed on stem cells and cancer. During her MSc, she has been awarded with UGC Postgraduate Merit Scholarship for University Rank Holder. She is a University Gold Medalist in Biomedical Sciences.
2. Dr Kriti Kaushik: Postdoctoral Research Fellow
Kriti joined the lab as a DBT-Research Associate (fellowship) in 2018 with an interest to decipher the role of long non-coding RNAs in regulating IGF2BP3 in aggressive cancers. She will be expanding her research investigation as a DHR Young Scientist to study another class of non-coding RNAs i.e. circular RNAs bound with IGF2BP3 and their mechanism of action in promoting metastasis during hypoxia in leukemia patients. With a strong background in genomics (during her PhD from CSIR-IGIB), Kriti is also keen to perform bioinformatic analysis of RNA-seq and related data.
3. Masters Students
Harsh is a final year M.Sc. student with keen interest in science and research. He is currently preparing for admissions in graduate school. He is working upon deciphering the role of METTL3 and IGF2BP synergism in leukemogenesis.
Ruchi is a final year Masters student. She is working to investigate the Synergistic effect of RNA- binding proteins, IGF2BP1/3 and methyltransferase, METTL14 in leukemogenesis. She is currently preparing for admission to graduate school.
5. Dr Sharath: Sharath is an MD student who has joined the lab recently. He will be working on the role of epitranscriptomic modifications in cancer.
6. Arjun Saraswat and Lajja Patel: Arjun and Lajja are MBBS students who have been selected by the institute’s UG Mentorship Research Scheme. They are working on the role of IGF2BP3 associated circular RNAs in hypoxia and epithelial to mesenchymal transition.
- Dr. Elza Boby: Elza worked on the ‘Role of IGF2BP1 in ETV6-RUNX1 translocation positive B-ALL’. She did her MD in Biochemistry in the lab and passed out in 2018. She is presently working at Calicut Medical College in the Department of Biochemistry as Assistant Professor.
- Sanjeev Goswami: Sanjeev worked on the ‘Role of IGF2BP3 in the invasion and migration of cancer cells’ during his Masters in Biochemistry (2016-2018) in our lab. He is presently enrolled as a PhD student in Prof Kunzang Chosdol’s lab in Biochemistry.
- Dr Thakur Nidhi: Nidhi worked on the ‘Role of EGFL7 in ETV6-RUNX1 translocation positive B-ALL’. She did her MD in Biochemistry in the lab and passed out in 2019. She is presently working as a Senior Resident in ESIC, Faridabad.
MBBS students for summer fellowships and short-term training are always welcome as long as you are willing to put in the hard work