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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Dr. Pragyan Acharya


Left to Right: (Back Row) Rohan Singh, Renuka, Rohini Saha, Charandeep Kaur, Roshan Marik, Rajendra Mandage, Atreyi Pramanik

(In the front) Dr. Pragyan Acharya

Name of Faculty Member: Pragyan Acharya, Ph.D.

Designation: Assistant Professor

Address: Room No. 3002, 3rd floor Teaching Block, Department of Biochemistry, AIIMS, New Delhi-29.

Official Phone: 26546431

Email id: dr.pragyan.acharyaATgmail.com

Social media links (If you wish to share):

https://in.linkedin.com/in/pragyan-acharya-40599b16

Short Biography (use template provided)

Academic Details (Add columns if required)

Degree

Subject

University/ Institution

Year

Ph.D.

Biochemistry

Indian Institute of Science, Bangalore

2011

M.S.

Biological Sciences (specialization Biochemistry)

Indian Institute of Science, Bangalore

2004

B.Sc. (H)

Biochemistry

Sri Venkateswara College, Delhi University

2001

Positions held: (Add columns if required)

Position

Department

University/ Institution

Dates

Assistant Professor

Biochemistry

AIIMS, New Delhi

October 2015-present

Visiting fellow

NIAID

National Institutes of Health, USA

February 2012-October 2015

Notable Awards and Society Memberships (500 words max)

GRANTS AND FELLOWSHIPS:

  • 2016-DST Early Career Award
  • 2016 AIIMS- Intra Mural Grant
  • Grant for 2017 EMBO Global Exchange Lecture Course entitled Malaria Genomics and Public Health.

AWARDS AND HONORS

  • Fellows Award for Research Excellence 2015- sponsored by the NIH Scientific Directors, the Office of Intramural Training & Education and FelCom/NIH.
  • Fellowship in the Khorana Nirenberg Scholars Program (US-India Career Transition Award- sponsored by DBT, India and NIH, USA) 2011
  • Ranbaxy Science Scholar 2010
  • Integrated Ph.D. Fellowship by Indian Institute of Science: 2001-2009

SOCIETY MEMBERSHIP

Indian Society of Translational Research

Proteomics Society of India

Human Proteome Organization

Indian Immunology Society

Research Focus of the Lab (upto 1000 words)

We work on different disease models to understand pathogenesis and discover biomarkers. We use a multitude of approaches such as proteomics, transcriptomics, metabolomics, immunological and cell biological assays to understand the immunopathogenesis of the following diseases:

(1) Organ Failure in Acute-on-chronic liver failure- a very complex disorder with very high short term mortality, believed to be mediated by innate immune responses gone awry. We are looking at the pathways that are dysregulated in ACLF in order to identify therapeutic targets to reverse this disease.

(2) Severe P. falciparum and P. vivax malaria: The malaria parasite is an expert in immune evasion and host immunomodulation. Our goal is to understand the host pathogen interactions during malaria infections that lead to suppression of host immune memory.

List of Current Lab members :

1. PI: Dr. Pragyan Acharya: PhD (Indian Institute of Science, Bengaluru) and Postdoctoral fellowship from NIH, USA


Our main interest in looking at immune mediated pathways in ACLF and Malaria. The natural World fascinates me and I love to read all kind of literature – scientific and non-scientific, to write both scientific and non-scientific literature, to paint and sketch

2. Post doctoral fellow: Rajendra Mandage


I am a bioinformatician interested in doing cutting edge research in infectious diseases. I love to travel read and do new experiments in the kitchen.

3. PhD Student: Rohini Saha


I am working on a fascinating project on innate immune dysfunction in ACLF. Baking is my stress buster. I like experimenting with age-old protocols, be it in Laboratory or in the Kitchen :) A cat-person by heart, but love petting and feeding street dogs. Watching F.R.I.E.N.D.S re-runs on weeknights is an all time hobby.

4. PhD Student: Komal Chauhan

I am working on the plasticity of macrophages in ACLF. I love playing volleyball and spending time with friends.

5. Junior Research Fellow: Renuka


I am working on the host-pathogen interactions in malaria and the influence of the parasite on host innate immune cells. My hobbies are playing table tennis, painting, visiting historical places and learning science.

6. Junior Research Fellow: Rohan Singh


I am working on the developing liquid biopsy based biomarkers in ACLF since my interests lie in translational research. In my free time I do horse riding, play badminton and play volleyball.

7. Junior Research Fellow: Atreyi Pramanik


I am interested in developing novel non-invasive biomarkers for enteropathy in Celiac disease. Towards this I am using Proteomics Approaches. My hobbies include cooking, listening to music and travelling.

8. M.Sc. Student: Roshan Marik


I am from the beautiful country of Nepal and am analyzing TNF alpha levels in severe malaria. My hobbies is Reading literature, visiting new places and also cooking.

1. K.David Raja: M.Sc. Biochemistry

I did my graduation from Deshbandhu College, DU. I am trying to establish plasma derived nucleic acids as a source of biomarkers in Acute Chronic Liver Failure (ACLF). My current hobby is playing football and reading comics

2. Akshay Munjal: M.Sc. Biochemistry


I did my graduation from Deshbandhu College, DU. I am trying to establish appropriate biomarkers for celiac disease using proteomics. My hobby is gardening. My field of interests is protein expression, purification and interaction studies

Key publications (Please limit to 10)

PUBLICATIONS

Original Research Papers

1. Kaur C*., Pramanik A*., Kumari K*, Mandage R., Dinda AK, Sankar J, Bagga A, Agarwal SK, Sinha A, Singh G, Acharya P. Renal Detection of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in Malaria Associated Acute Kidney Injury: A Retrospective Case-Control Study (Accepted BMC Res N 2020)
* Equal contributors
2. Acharya P*, Kutum R*, Pandey R*, Mishra A, Saha R, Munjal A, Ahuja V, Mukerji M, Makharia GK. First Degree Relatives of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect them from Enterocyte Damage. Clin Transl Gastroenterol. 2018 Oct 8;9(10):195. doi: 10.1038/s41424-018-0059-7.
* Equal contributors
3. Alampalli SV*, Grover M*, Chandran S, Tatu U, Acharya P. Proteome and Structural Organization of the Knob Complex on the Surface of the Plasmodium Infected Red Blood Cell. Proteomics Clin Appl. 2018 Jul;12(4):e1600177. doi:10.1002/prca.201600177.
* Equal contributors
4. Acharya P, Chaubey S, Grover M, Tatu U. An Exported Heat Shock Protein 40 Associates with Pathogenesis-Related Knobs in Plasmodium falciparum Infected Erythrocytes. PLoS One. 2012;7(9):e44605. Epub 2012 Sep 7. doi: 10.1371/journal.pone.0044605
5. Acharya P*, Pallavi R*, Chandran S, Dandavate V, Sayeed SK, Rochani A, Acharya J, Middha S, Kochar S, Kochar D, Ghosh SK, Tatu U. Clinical proteomics of the neglected human malarial parasite Plasmodium vivax. PLoS One. 2011;6(10):e26623. Epub 2011 Oct 20. doi: 10.1371/journal.pone.0026623
*Equal contributors
6. Acharya P*, Pallavi R*, Chandran S, Chakravarti H, Middha S, Acharya J, Kochar S, Kochar D, Subudhi A, Boopathi AP, Garg S, Das A, Tatu U. A glimpse into the clinical proteome of human malaria parasites Plasmodium falciparum and Plasmodium vivax. Proteomics Clin Appl. 2009 Nov; 3(11):1314-25. doi: 10.1002/prca.200900090.
* Equal contributors
Selected as “Editor’s Choice” in Science (2010) Vol. 327, pp 13.
7. Pallavi R*, Acharya P*, Chandran S, Daily JP, Tatu U. Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients. Malar J. 2010 Aug 19;9: 236. doi: 10.1186/1475-2875-9-236.
* Equal contributors
8. Pesce ER, Acharya P, Tatu U, Nicoll WS, Shonhai A, Hoppe HC, Blatch GL. The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns. Int J Biochem Cell Biol. 2008;40(12):2914-26. Epub 2008 Jul 12. doi: 10.1016/j.biocel.2008.06.011

Reviews

1. Singh A, Pramanik A, Acharya P, Makharia GK. Non-Invasive Biomarkers for Celiac Disease. J Clin Med. 2019 Jun 21;8(6). pii: E885. doi: 10.3390/jcm8060885.
2. Acharya P, Garg M, Kumar P, Munjal A, Raja KD. Host-Parasite Interactions in Human Malaria: Clinical Implications of Basic Research. Front Microbiol. 2017 May 18;8:889. doi: 10.3389/fmicb.2017.00889. eCollection 2017.
3. Acharya P, Kumar R, Tatu U. Chaperoning a cellular upheaval in malaria: heat shock proteins in Plasmodium falciparum. Mol Biochem Parasitol. 2007 Jun;153(2):85-94. Epub 2007 Jan 17.
 
Book Chapters
1. Duffy P E, Acharya P and Oleinikov A. Cytoadherence of the Malaria Parasite. Encyclopedia of Malaria. Springer Publications. (Accepted 2014)
2. Acharya P, Grover M and Tatu U. Systems Biology of Malaria in Encyclopedia of Systems Biology. Springer Publications. 2013.

We would like to acknowledge funding from AIIMS Intramural Grant ,SERB and DBT for supporting our work.

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