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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi
कॉल सेंटर:  011-26589142

Research

RESEARCH ( Year 2019-20)

Funded projects

 

ONGOING

S. No.

Title of the project

Name of Principal Investigator

Funded by (Name of funding agency)

Duration (years)

Start year–End year

Total funds sanctioned (Rs)

1

A Label Extension, Single Arm Multicentric Phase III Study To Assess The Efficacy And Safety Of Approved Product Stempeucel® In Patients With Critical Limb Ischemia Due To Buerger’s Disease

Prof. Anita Dhar

StempeuticsPvt. Ltd.

05 years

2018-23

07 lacs

2

A Label Extension, Single Arm Multicentric Phase III Study To Assess The Efficacy And Safety Of Approved Product Stempeucel® In Patients With Critical Limb Ischemia Due To Atherosclerotic Peripheral Arterial Disease

Prof. Anita Dhar

StempeuticsPvt. Ltd.

05 years

2019-24 years

03 lacs

3.

A Study of gut microbiome in patients with gall bladder carcinoma

Asuri Krishna

AIIMS,

New Delhi

2 years

2019-2021

10 laks

4.

To check the feasibility of aortic balloon dilatation catheter for endovascular occlusion of aorta- a cadaveric study

Mohit Kumar Joshi

Research Section AIIMS

1 year

2019

Rs 75,000/-

5.

Complete estrogen Blockade in recalcitrant mastalgia: A randomized clinical trial

Suhani

Intramural

research grant

02 years

2018-ongoing

INR 4,99,680

 

6.

LongTerm Outcome of Patients with Walled off Necrosis/Pseudocystof Pancreas in terms of Recurrence of Acute Pancreatitis, Fluid Collection and Functional Consequences following Internal Drainage by Laparoscopic or Endoscopic method".

Om Prakash

AIIMS,

New Delhi

2 years

2019-2021

10 laks

 

COMPLETED

 

S. No.

Title of the project

Name of Principal Investigator

Funded by (Name of funding agency)

Duration (years)

Start year – End year

Total funds sanctioned (Rs)

1.

To study the pattern of FOXP3, OX40, PD1, and TIM-3among renal allograft patients and its correlation with risk of kidney injury

Manjunath Maruti Pol

Intramural funds

2 years

September 2019

 

 

DEPARTMENTAL PROJECTS

(Including thesis/dissertations)

ONGOING

 

S. No.

Title of the project

1

Development of aptamer-based assay for diagnosis of breast tuberculosis (TB breast)

2

Comparison of quality of life between patients undergoing endoscopic thyroidectomy and open thyroid surgery.

3

A study of fluorescein spectrometry, indocyanine green imaging, Raman spectrometry and Doppler flowmetry analysis comparing malignant and benign lesions of breast.

4

A Randomized controlled trial to compare efficacy of complete decongestive therapy vs complete decongestive therapy and placement of hydrophobic silicone tube and look for their long term patency by ICG in upper limb lymphedema following ALND in breast cancer

5

Comparison of identification rate and cost effectiveness of Indocyanine green vs fluorescein for sentinel lymph node detection in ladies with operable breast cancer - Arandomized controlled trial

6

Diagnostic study evaluation in patients presenting with sign and symptoms of abdominal and inguinoscrotal region

7

Randomized controlled study comparing stainless steel clip with silicone tube tip for localization of breast cancer after neoadjuvant chemotherapy within patients with breast cancer. A Non-inferiority study.

8

Validation of a careful clinical examination with venous Doppler studies in the management of patients presenting with varicose veins

9

Comparison of Quality of Life and oncological outcomes of Skin Sparing Mastectomy with Autologous Fat Grafting versus Skin Sparing Mastectomy with silicone implant versus Breast Conservative Therapy among ladies with Early Breast Cancer: A Randomized comparison

10

A randomized control study to evaluate the use of oral metronomic chemotherapy versus conventional systemic chemotherapy, and to further conduct a randomized control trial on patients amenable to breast conservation surgery after chemotherapy.

11

Comparison of Cost Effectiveness and Quality of Life in patients undergoing a level 1 vs. Complete Axillary Lymph Node Dissection for operable breast cancer: An Ambispective study

12

Randomized Trial to Compare Effectiveness Of Vacuum Suction Drainage Versus Needle Aspiration In Lactational Breast Abscess: Superiority Hypothesis Trail

13.

To study causes of cancellation among patients scheduled for elective operations

14.

To assess the functional outcomes in patients undergoing standardized laparoscopic mesh repair in small and medium ventral midline hernias.

15.

 

To assess the cost effectiveness of laparoscopic standardized laparoscopic mesh repair in ventral hernia.

16.

 

To study the complications of laparoscopic inguinal repair.

17.

Symptomatic outcomes in patients of asymptomatic gall stones after laparoscopic cholecystectomy.

18.

Study the significance of tumor infiltrating lymphocytes in breast cancer

19.

Outcomes of Minimal Access Thymectomy of patient with Thymoma.

20.

Prospective randomized control trial comparing angle of his accentuation v/s Toupet fundoplication as a anti reflux procedure in patients of achalasia cardia undergoing Heller’s Cardiomyotomy.

21.

Feasibility of enhanced recovery after surgery protocol in general thoracic surgery: prospective cohort study.

22.

Comparison of learning curve on Two-Dimensional (2D) endo-vision system, Ultra-High Definition (HD) (4K) endo-vision system and three-dimensional (3D) HD endo-vision system for standardized phantom tasks: An ex-vivo study.

 

23.

 

Incidence of Barret’s Esophagus in Morbidly Obese Patients after Laparoscopic Sleeve Gastrectomy

24.

Study effect of Bariatric Surgery induced weight loss on urinary incontinence

25.

A prospective randomized control study to compare antral resection versus antral preservation during Laparoscopic Sleeve Gastrectomy for Morbidly Obese.

26.

Electrolyte and acid-base disturbances in renal transplant patients – A prospective observational study

27.

Prospective Open Label clinical trial for evaluating the feasibility, safety and efficacy of left gastric artery embolization for reduction of the weight in class I obesity.

28.

To determine the non-invasive investigations which correlate with liver biopsy in extent of fibrosis in morbidly obese patients undergoing bariatric surgery.

29.

Comparison between banded and Non- Banded Laparoscopic Sleeve Gastrectomy for Weight Loss in Obese subjects.

A Randomized Controlled Trial.

30.

Analysis of genes related to metabolic flexibility in subjects undergoing weight reduction surgery

31.

Short term and long term outcomes following laparoscopic donor nephrectomy and open donor nephrectomy : An Ambispective comparative study

32.

A Prospective Randomized trial comparing Laparoscopic Vs Endoscopic drainage for Walled Off Necrosis following Acute Pancreatitis

33.

Incidence of Postoperative Hypocalcemia after Indocyanine Green Fluorescence guided Vs Conventional assessment of Parathyroid Function following Total thyroidectomy- A Randomized Controlled Trial

34.

Improving Pain management Following Laparoscopic surgery: A Randomized Quality Improvement study

35.

A prospective study to evaluate the restoration of abdominal wall dynamics in patients with incisional hernia following laparoscopic IPOM plus repair in comparison to healthy controls using surface EMG.

36.

To study the correlation between pre-operative pain threshold measured using Quantitative Sensory Testing with post-operative pain scores using Visual Analogue Score in patients with laparoscopic groin hernia repair

37.

Effect of Yoga Therapy on Quality of Life in Patients Undergoing Laparoscopic Incisional and Ventral Hernia Repair- A Randomized Control Trial

38.

Comparison of eTEP vs IPOM for Management of Primary and Incisional Hernia in Terms of Early Outcomes and Cost Effectiveness – A Randomized Controlled Trail.

39.

Comparison of Early Outcomes of Interrupted Double ‘X’ suture vs Continuous Near Far- Far Near Method for closure of abdominal wall incisions : A Double Blinded Randomized Control Trial

40.

Long Term outcome of patients with Benign Breast Diseases An ambispective Study

41.

Decision analysis approach in management of non lactational mastitis

42.

Use of Platelet rich plasma in management of diabetes with PAD

43.

Nipple discharge in women; Evaluation and Randomized trial comparing limited length ductal cone excision (1.5 cm) with 3 cm ductal cone excision in women presenting with non-bloody nipple discharge.

44.

Association of different modalities of treatment with expression of various subsets of T lymphocytes in patients with breast cancer and their clinical outcome

45.

Randomized trial to compare effectiveness of vacuum suction drainage versus needle aspiration in lactational breast abscess: superiority hypothesis trial

46.

A Randomized control trial to compare the safety and outcome of trans-oral vestibular vs axillo-breast approach for endoscopic hemi-thyroidectomy in patients with benign thyroid swellings.

47.

A study of fluorescein spectrometry, indocyanine green imaging, Raman spectrometry and Doppler flowmetry analysis comparing malignant and benign lesions of breast.

48.

To evaluate the role of age adjusted Charlson comorbidity index scoring in predicting 30 day post operative outcomes in patients undergoing surgery under general and regional anaesthesia

49.

Comparison of learning curve on Two-Dimensional (2D) endovision system, Ultra-High Definition (HD) (4K) endovision system and three-dimensional (3D) HD endovision system for standardized phantom tasks: An ex-vivo study

50.

Mesh fixation with penetrating fixation device versus fibrin sealant during laparoscopic repair of ventral hernia: A double blind randomised control trial

51.

Neoadjuvant Chemotherapy with Short Course Radiotherapy for Locally Advanced rectal cancer: A Pilot Study

52.

Short term and long term outcomes following laparoscopic donor nephrectomy and open donor nephrectomy :

An Ambispective comparative study

53.

A study to evaluate the predictors of outcome in patients with blunt liver trauma Prospective Observational study

54.

To study the correlation between pre operative pain threshold measured using Quantitative Sensory Testing with

post operative pain scores using Visual Analogue Score in patients with laparoscopic groin hernia repair - A case

control study

55.

A prospective study to evaluate the restoration of abdominal wall dynamics in patients with incisional hernia

following laparoscopic IPOM plus repair in comparison to healthy controls using surface EMG

56.

Improving Pain Management following Laparoscopic Surgery: A Randomized Quality Improvement Study

57.

A prospective randomized trial comparing laparoscopic versus endoscopic drainage for walled off necrosis

following acute pancreatitis

58.

Comparison of Early Outcomes of Interrupted Double 'X' suture vs Continuous Near Far- Far Near Method for

closure of abdominal wall incisions : A Double Blinded Randomised Control Trial

59.

To study the usefulness of pre-operative USG guided FNAC in avoiding radical surgery in patients with

gallbladder wall thickness or polyp associated with gall stone disease.

60.

Follow up Study to Evaluate Correlation of Imaging and Operative findings with Clinical and Biochemical

Outcome in Patients with Primary Hyperparathyroidism

61.

Comparison of eTEP vs IPOM for Management of Primary and Incisional Hernia in Terms of Early Outcomes

and Cost Effectiveness - A Randomized Controlled Trail.

62.

Effect Of Yoga Therapy On Quality Of Life In Patients Undergoing Laparoscopic Incisional And Ventral Hernia

Repair- A Randomized Control Trial"-

63.

Comparison of eTEP vs IPOM for Management of Primary and Incisional Hernia in Terms of Early Outcomes

and Cost Effectiveness - A Randomized Controlled Trail.

64.

Effect Of Yoga Therapy On Quality Of Life In Patients Undergoing Laparoscopic Incisional And Ventral Hernia

Repair- A Randomized Control Trial

65.

Biochemistry Phd thesis: Investigation of the involvement of plasma membrane ATP binding transporter A1 (ABCA1) mediated insulin resistance.

66.

Comparison between banded and non-banded laparoscopic sleeve gastrectomy for weight loss in obese subjects: A randomized controlled study

67.

To determine the best non-invasive marker or a combination of them correlate the most with liver biopsy in extent of fibrosis in morbidly obese patients with non-alcoholic fatty liver disease undergoing bariatric surgery.

68.

Standardized umbilical hygiene to reduce port site complications in laparoscopic cholecystectomy –A prospective randomized controlled study.

69.

Outcomes of laparoscopic sleeve gastrectomy with or without hiatal hernia repair in terms of resolution of symptoms of GERD

70.

Omega loop gastric bypass (mini gastric bypass) versus Roux-en-Y gastric bypass for resolution of type-II diabetes Mellitus in obese subjects: A Prospective Randomized controlled trial

71.

To assess the functional outcomes in patients undergoing standardized laparoscopic mesh repair in small and medium ventral midline hernias.

72.

Evaluation of Dual dye technique for sentinel lymph node biopsy in breast cancer: Two arm open label parallel design Non-inferiority Randomized controlled trial.

73.

To Establish an algorithm for the management of axilla in patients of early operable breast cancer with clinically negative axilla.

74.

Oncological outcomes of breast conservation surgery in patients with locally advanced breast cancer post neoadjuvant chemotherapy.

75.

 

Assessment of post cholecystectomy symptoms and quality of life evaluation: A prospective cohort study

76.

 

Short term and long term outcomes following laparoscopic donor nephrectomy and open donor nephrectomy :

An Ambispective comparative study

77.

To study the correlation between pre operative pain threshold measured using Quantitative Sensory Testing with

post operative pain scores using Visual Analogue Score in patients with laparoscopic groin hernia repair - A case

control study

78.

A prospective study to evaluate the restoration of abdominal wall dynamics in patients with incisional hernia

following laparoscopic IPOM plus repair in comparison to healthy controls using surface EMG

79.

A prospective randomized trial comparing laparoscopic versus endoscopic drainage for walled off necrosis

following acute pancreatitis

80.

To study the usefulness of pre-operative USG guided FNAC in avoiding radical surgery in patients with

gallbladder wall thickness or polyp associated with gall stone disease.

81.

Follow up Study to Evaluate Correlation of Imaging and Operative findings with Clinical and Biochemical

Outcome in Patients with Primary Hyperparathyroidism

 

COMPLETED

 

S. No.

Title of the project

1

Comparison of efficacy of Ormeloxifene and Tamoxifen in the treatment of cyclical mastalgia: A five-armed double-blinded randomised controlled trial

2

Validation of different methods of physical examination of breast and axilla in patients with breast diseases: a cross-sectional study.

3

The effect of 1cm vs. 2cm resection margin and oncoplastic closure of breast parenchymal defect on oncological and aesthetic outcome in ladies with early breast cancer: a 2x2 factorial randomized controlled trial.

4.

Comparison of mesotherapy (non operative) with surgery in management of superficial lipoma.

5.

Pilot study on parathyroid dissection and preservation from thyroidectomy specimen and correlation with postoperative calcium and parathormone levels.

6.

Study port placement and ergonomics in laparoscopic splenectomy.

7.

Surgical outcome in geriatric population.

8.

To define surgical outcome in patients who are converted to minimally invasive surgery to open procedure.

9.

Prospective randomized control trial comparing angle of his accentuation v/s Toupet fundoplication as a anti reflux procedure in patients of achalasia cardia undergoing HellersCardiomyotomy

10.

The feasibility and safety of the sub-xiphoid video assisted thymectomy for myasthenia gravis: A pilot study.

11.

Study of Androgen Receptors mediated events and molecular heterogencity in Breast Cancer.

12.

Isolation, identification and characterization of cancer stem cells from different histopathological grades of colorectal carcinoma.

13.

A study of physiological outcome and correlation with symptomatic outcome following laparoscopic Heller cardiomyotomy in primary Achalasia cardia.

14.

Comparison of three-dimensional (3D) endo-vision system versus ultra-high definition (HD) (4K) endo-vision system in minimally invasive surgical procedures-An open labelled randomized study.

15.

Study the impact of Bariatric Surgery induced weight loss on cardiovascular disease risk reduction in morbid obese patients

 

16.

Omega Loop Gastric Bypass versus Roux En Y Gastric Bypass for type 2 diabetes mellitus in obese subjects:

A Randomized Controlled Trial

 

17.

Study the impact of Laparoscopic Mini Gastric Bypass on weight loss and co morbidities in morbidly obese patients undergoing Bariatric Surgery

18.

Impact of Nutritional & Lifestyle Modifications in Subjects with BMI 25-29.9 vs 30-34.9 Kg/m a and Impact of Bariatric Surgery in BMI > 35 Kg/m2

19.

A study to evaluate the predictors of outcome in patients with blunt liver trauma Prospective Observational study

20.

A study of gut microbiome in patients with gallbladder cancer

21.

ICG fluorescence imaging for identifying and assessing the perfusion of parathyroid gland during thyroid surgery

22.

Stent vs no stent in ureteroneocystostomy in live related renal transplant: a prospective randomized controlled trial

23.

Ergonomic analysis of muscle activity during laparoscopy and influence of training

24.

Follow up Study to Evaluate Correlation of Imaging and Operative findings with Clinical and Biochemical Outcome in Patients with Primary Hyperparathyroidism.

25.

Three Arm Randomized Comparison of Laparoscopic Peritoneal Dialysis Catheter Insertion with or Without Omentectomy Versus Conventional Open Peritoneal Dialysis Catheter Insertion in Chronic Kidney Disease Stage 5 Patients in Terms of Catheter Malfunction and Post-operative Complications

26.

A Three Arm Randomized Controlled Study to Compare Sexual Functions Following Open Mesh Hernioplasty, Laparoscopic Totally Extra Peritoneal (TEP) and Trans Abdominal Pre-Peritoneal (TAPP) Repair of Groin Hernia

27.

Dosimetric Study in children and young adults with Differentiated Thyroid Cancer undergoing Radioiodine (131I- Na) therapy.

28.

A randomized controlled trial to compare decongestive compression therapy (DCT), DCT with inj. BPG and hydrophobic silicone tube placed drainage in lymphedema of upper limb post breast cancer treatment.

29.

A randomized controlled trial to compare decongestive compression therapy (DCT), DCT with inj BPG and hydrophobic silicone tube placed drainage in lymphedema of upper limb post breast cancer treatment.

30.

Comparison Of Oncologic And Functional Outcomes In Ladies With Breast Cancer Treated With Breast Conservation Compared To Those Treated With Mastectomy: An Ambispective Study

31.

Validation of different methods of physical examination for swelling in thyroid region and sonographic corelation - a cross- sectional study

32.

A Two Arm Parallel Design Superiority Randomised Trial Comparing Penicillin +Standard Of Care Vs Standard Of Care Alone In Achieving Complete Healing Of Leg Ulcers In Patients With Chronic Venous Hypertension

33.

Comparison of Two-Dimensional (2D) endovision system, Ultra-High Definition (HD) (4K) endovision system and three-dimensional (3D) HD endovision system on standardized phantom tasks: An ex-vivo study

34.

Pilot study on parathyroid dissection and preservation from thyroidectomy specimen and correlation with postoperative calcium and parathormone levels.

35.

To define surgical outcome in patients who are converted to minimally invasive surgery to open procedure.

36.

Evaluation of gamma synuclein as a serum bio-marker in breast cancer.

 

COLLABORATIVE PROJECTS

 

ONGOING

S. No.

Title of the project

Collaborating department/institution

1

A prospective randomized controlled study to compare the effectiveness of moist occlusive honey dressing Vs. JatyadiTaila dressing in complete healing of dushtavrana (Chronic Wound)

Department of Shalya Tantra, All India Institute of Ayurveda (An Autonomous Organization under Ministry of Ayush, Govt. of India)

2.

Immunohistochemical and quantitative analysis of cytokeratin and cKIT in gastrointestinal and respiratory neuroendocrine tumours

Anatomy, AIIMS

3.

Studying the role of WnT non-canonical pathway in sustaining colorectal cancer stem cells (CSC) and evaluating its role in cancer stem cell metabolism.

Biochemistry, AIIMS

4.

Unravelling the role of novel proteins in gastroenteropancreatic and respiratory neuroendocrine tumours

Anatomy, AIIMS

5.

Elucidating the role of differential expressed genes in colorectal cancer stem cells

Biochemistry, AIIMS

 

6.

Extracellular Matrix Remodelling In Obesity Induced Adipose Tissue Dysfunctions And Insulin Resistance

Biochemistry, AIIMS

 

7.

Study Of Vascular Endothelial Growth Factor (VEGF) And Its Isoforms In Obesity Associated Adipose Tissue Dysfunctions

 

Biochemistry, AIIMS

8.

The Modulation of Insulin resistance and HDL quality by adipose tissue ABCA1 and metabolic status

Biochemistry, AIIMS

9.

Efficacy and safety of Semaglutide 2.4 mg once weekly in subjects with overweight and obesity

Endocrinology, AIIMS

10.

Role of T-Regulatory cells (T-regs) in obesity and their clinical correlation in obesity associated inflammation in type 2 diabetic and chronic kidney disease (CKD)

 

Nephrology, AIIMS

11

Development of labyrintinth based mechanical and fast isolation technique for identifying circulating tumour cells of colorectal carcinomas for metastatic evaluation

Pathology, AIIMS

 

12

A molecular and immunohistochemical study of human colorectal carcinomas to classify them according to the consensus molecular subtypes and to evaluate its prognostic and therapeutic relevance

Pathology, AIIMS

 

13

To study the role of regulatory T cells in immune suppression in patient with colorectal cancer

Transplant Immunology and Immunogenetics

 

COMPLETED

S. No.

Title of the project

Collaborating department/institution

1

Endoplasmic Reticulum (ER) Stress in Obesity Induced Adipose Tissue Dysfunction and Inflammation

Biochemistry, AIIMS

 

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