पाठ्यक्रम

Full Name

Dr. Aruna Nambirajan

Qualifications

MD (Pathology), DNB

Office Address

3015, Third Floor, Convergence Block, AIIMS, New Delhi, 110029

Specialty

Pulmonary pathology (neoplastic and non-neoplastic), Cytopathology, Neuropathology

Areas of academic and research interest

Lung cancer, Molecular diagnostics, Pulmonary cytology, Non-neoplastic lung diseases, Thymic neoplasms, Digital pathology

Notable Awards and Honors

• MBBS (Best Outgoing MBBS student, Chengelpet Govt. Medical College, Tamilnadu)
• MD Pathology (Best Outgoing Junior Resident, AIIMS, New Delhi, Dr V Ramalingaswamy Gold Medal)
• DNB Pathology (All India Topper, NBE President’s Gold Medal)
• Dr V R Khanolkar Award, APCON, (2014)
• ISNO (Indian Society of Neuro-oncology) President’s Annual award for best student in Clinical Neuro-Oncology, ISNOCON, Hyderabad, 2016
• Colonel DB Nayar Memorial Award for best paper in the field of molecular cytopathology, AC of IAC, Shillong, 2017
• Certificate of Excellence (Basic research Category), AIIMS foundation day, 2018- first author in winning publication
• Young Investigator Travel award, International Congress of Neuropathology, Japan, 2018
• AIIMS Oncology Award (Basic Research Category) 2^nd place, 2019 – co-author in winning publication
• AIIMS Oncology Award (Basic Research Category) 1^st place, 2020 – first author in winning publication
• Developing Nations Award – Winning Finalist, World Conference on Lung Cancer, Worldwide Virtual Event, 2021

Books and chapters

• Nambirajan A., Jain D. (2021) Immunohistochemical Detection of p40 Expression in Lung Cancer Clinical Samples. In: Santiago-Cardona P.G. (eds) Lung Cancer. Methods in Molecular Biology, vol 2279. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1278-1_2
• Nambirajan A, Singh V, Jain D. Molecular pathology of thymic epithelial tumors. In: Atlas of Thymic Pathology; Eds: Jain D, Bishop JA, Wick MR. Springer 2020: pgs. 169-172
• Nambirajan A. (2020) Infectious diseases. In: Eds. Singh MK, Kumar V. Robbins and Cotran Pathologic Basis of Disease: Vol II, 10e - South Asia Edition, pgs. 1332-1333
• Nambirajan A., Sharma A., Sharma M.C. (2021) Pathology and Molecular Pathology of Ependymoma. In: Mallick S., Giridhar P., Rath G.K. (eds) Evidence based practice in Neuro-oncology. Springer, Singapore. https://doi.org/10.1007/978-981-16-2659-3_4
• Nambirajan A., Singh J., Suri V. (2021) Pathology and Molecular Pathology of Meningioma. In: Mallick S., Giridhar P., Rath G.K. (eds) Evidence based practice in Neuro-oncology. Springer, Singapore. https://doi.org/10.1007/978-981-16-2659-3_5
• Giridhar P., Nambirajan A., Benson R. (2021) Ependymoma. In: Mallick S., Giridhar P., Rath G.K. (eds) Evidence based practice in Neuro-oncology. Springer, Singapore. https://doi.org/10.1007/978-981-16-2659-3_24
• Suri V, Nambirajan A, Sharma MC, Sarkar C. Surgical Pathology of intractable epilepsy. In. Progress in clinical neurosciences, Volume 30; Eds: Muthukumar N and Goyal V, Thieme Delhi, 2016: pgs 13-32.
• Nambirajan A, Sharma MC. Ependymal tumors. In. Essentials of Diagnostic Surgical Neuropathology; Eds: Sarkar C, Santosh V, Chacko G. Thieme Delhi 2018: pgs 41-49. 

Top Research publications

1. Nambirajan A, Kaur H, Jangra K, et al. Adenocarcinoma predominant pattern subtyping and nuclear grading in cytology: Is there a role in prognostication of advanced pulmonary adenocarcinomas? Cytopathology. 2018;29:163-171. 
2. Nambirajan A, Longchar M, Madan K, Mallick SR, Kakkar A, Mathur S, Jain D. Endobronchial ultrasound guided transbronchial needle aspiration cytology in patients with known or suspected extra-pulmonary malignancies: A cytopathology based study. Cytopathology. 2018;30:82-90.
3. Nakra T, Nambirajan A, Guleria P, Phulware R, Jain D. Insulinoma-associated protein 1 is a robust nuclear immunostain for the diagnosis of small cell lung carcinoma in cytology smears. Cancer Cytopathol. 2019;127:539-548.
4. Singh V, Nambirajan A, Malik PS, Thulkar S, Pandey RM, Luthra K, Arava S, Ray R, Mohan A, Jain D. Spectrum of uncommon and compound epidermal growth factor receptor mutations in non-small cell lung carcinomas with treatment response and outcome analysis: a study from India. Lung Cancer. 2020;149:53-60.
5. Singh V, Nambirajan A, Malik PS, Kaur K, Mohan A, Jain D. EGFR mutation testing in cytology smears of advanced non-small cell lung carcinomas: practical applications in low resource laboratories. Cytopathology. 2021; 32:287-289.
6. Nambirajan A, Singh V, Bhardwaj N, Mittal S, Kumar S, Jain D. SMARCA4/BRG1-deficient non-small cell lung carcinomas: a case series and review of the literature. Arch Pathol Lab Med. 2021;145:90-98.
7. Nambirajan A, Dutta R, Malik PS, Bubendorf L, Jain D. Cytology of SMARCA4-deficient thoracic neoplasms: comparative analysis of SMARCA4-deficient non-small cell lung carcinomas and SMARCA4-deficient thoracic sarcomas. Acta Cytol. 2021;65:67-74.
8. Satapathy S, Singh V, Nambirajan A, Malik PS, Tanwar P, Mehta A, Suryavanshi M, Thulkar S, Mohan A, Jain D. EGFR mutation testing on plasma and urine samples: A pilot study evaluating the value of liquid biopsy in lung cancer diagnosis and management. Curr Probl Cancer. 2021 Mar 3:100722. doi: 10.1016/j.currproblcancer.2021.100722. Epub ahead of print.
9. Dutta R, Nambirajan A, Mittal S, Roy SC, Jain D. Cytomorphology of primary pulmonary NUT carcinoma in different cytology preparations. Cancer Cytopathol. 2021;129:53-61.
10. Ray A, Jain D, Goel A, Agarwal S, Swaroop S, Das P, Arava SK, Mridha AR, Nambirajan A, Singh G, Arulselvi S, Mathur P, Kumar S, Sahni S, Nehra J, Nazneen, Bm M, Rastogi N, Mahato S, Gupta C, Bharadhan S, Dhital G, Goel P, Pandey P, Kn S, Chaudhary S, Keri VC, Chauhan VS, Mahishi N, Shahi A, R R, Gupta BK, Aggarwal R, Soni KD, Nischal N, Soneja M, Lalwani S, Sarkar C, Guleria R, Wig N, Trikha A. Clinico-pathological features in fatal COVID-19 infection: a preliminary experience of a tertiary care center in North India using postmortem minimally invasive tissue sampling. Expert Rev Respir Med. 2021 Jul 24:1-9. doi: 10.1080/17476348.2021.1951708.

Ongoing Research Projects

• Molecular mechanisms of drug resistance in non-small cell lung carcinoma (AIIMS intramural collaborative – ongoing)
• Corticotrope pituitary adenomas (ICMR funded – ongoing)
• Spinal ependymomas (AIIMS funded – ongoing)

Links

https://www.ncbi.nlm.nih.gov/pubmed/?term=Nambirajan+A%5Bauthor%5D https://scholar.google.com/citations?user=JLJ-uBwAAAAJ&hl=en

https://www.researchgate.net/profile/Aruna-Nambirajan

Full Name

Dr. Kavneet Kaur

Qualifications

MD (Pathology)

Office Address

Room no. 3004, third floor, Convergence Block, Department of Pathology

Specialty

Head and neck pathology, Neuropathology

Areas of academic and research interest

Head and neck cancer, non-neoplastic diseases of head and neck

Notable Awards and Honors

• Shri Mohan Lal Wig Medal for best clinical research in AIIMS, 2015
• Young Scientist’s award at Asian Society for Neuro Oncology (ASNO) held at Osaka, Japan, 2017
• Smt Kunti Devi Mehrotra Award for best published paper in Annual conference of IAPM, 2016
• VR Khanolkar Award for best published paper in Annual conference of IAPM, 2018
• Herbert Krausse Award for Best paper in Neuro Oncology at the 66th Annual Conference of Neurological Society of India (NSICON), 2017
• V. Ramalingaswami Award for best oral presentation at Annual conference of IAPM-Delhi Chapter, 2016

Books and chapters

• Kavneet Kaur, Aanchal Kakkar, Chitra Sarkar. Embryonal tumors. In: Chitra Sarkar, Vani Santosh, Geeta Chacko (eds). Essentials of Diagnostic Neuropathology. Thieme 2017
• Suvendu Purkait, Kavneet Kaur, Vaishali Suri. Glial and glioneuronal tumors. In: Chitra Sarkar, Vani Santosh, Geeta Chacko (eds). Essentials of Diagnostic Neuropathology. Thieme 2017
• Kavneet Kaur, Chitra Sarkar. Pathology and Molecular Biology of Medulloblastoma. In:  Mallick S., Giridhar P., Rath G.K. (eds) Evidence based practice in Neuro-oncology. Springer, Singapore. https://doi.org/10.1007/978-981-16-2659-3_5
• Kavneet Kaur. Neoplasia (South Asia content). In: Singh MK, Kumar V (eds). Robbins and Cotran Pathologic Basis of Disease: South Asia Edition, 10th ed. Elsevier, 2020

Top Research publications

1. Kaur K, Kakkar A, Kumar A, Mallick S, Julka PK, Gupta D, Suri A, Suri V, Sharma MC, Sarkar C. Integrating molecular subclassification of medulloblastomas into routine clinical practice: a simplified approach. Brain Pathol. 2016;26:334-343.
2. Kaur K, Kakkar A, Kumar A, Purkait S, Mallick S, Suri V, Sharma MC, Julka PK,  Gupta D, Suri A, Sarkar C. Clinicopathological characteristics, molecular subgrouping, and expression of miR-379/miR-656 cluster (C14MC) in adult medulloblastomas. J Neurooncol. 2016;130:423-430.
3. Kaur K, Jha P, Pathak P, Suri V, Sharma MC, Garg A, Suri A, Sarkar C. Approach to molecular subgrouping of medulloblastomas: Comparison of NanoString nCounter assay versus combination of immunohistochemistry and fluorescence in-situ hybridization in resource constrained centres. J Neurooncol. 2019;143:393-403.
4. Kaur K, Rajeshwari M, Gurung N, et al. Uterine tumor resembling ovarian sex cord tumor: A series of six cases displaying varied histopathological patterns and clinical profiles. Indian J Pathol Microbiol. 2020;63(Supplement):S81–S86.
5. Kakkar A, Nambirajan A, Kaur K, Kumar A, Mallick S, Suri V, Sarkar C, Kale SS, Garg A, Sharma MC. ATRX loss in glioneuronal tumors with neuropil-like islands indicates similarity to diffuse astrocytic tumors. J Neurooncol. 2016 Oct;130(1):63-68.
6. Vallonthaiel AG, Jain D, Singh V, Kaur K, Madan K, Kumar V, Iyer VK, Sharma MC. c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas. Acta Cytol. 2017;61(1):77-83.
7. Pal J, Patil V, Kumar A, Kaur K, Sarkar C, Somasundaram K. Loss-of-function mutations in Calcitonin receptor (CALCR) identify highly aggressive glioblastoma  with poor outcome. Clin Cancer Res. 2018 Mar 15;24(6):1448-1458.
8. Kakkar A, Kaur K, Verma A. Pediatric mediastinal germ cell tumors. Mediastinum 2019;3:30.
9. Nambirajan A, Kaur H, Jangra K, Kaur K, Madan K, Mathur SR, Iyer VK, Jain D. Adenocarcinoma predominant pattern subtyping and nuclear grading in cytology – Is there a role in prognostication of advanced pulmonary adenocarcinomas? Cytopathology 2018; 29: 163-171.
10. Jha P, Manjunath N, Singh J, Mani K, Garg A, Kaur K, Sharma MC, Raheja A, Suri A, Sarkar C, Suri V. Analysis of PD-L1 expression and T cell infiltration in different molecular subgroups of diffuse midline gliomas. Neuropathology. 2019 Dec;39(6):413-424.

Ongoing Research Projects

• Mucormycosis in COVID-19 (AIIMS funded – ongoing)

Links

https://www.researchgate.net/profile/Kavneet-Kaur

https://scholar.google.com/citations?hl=en&user=QoZHcVYAAAAJ&scilu=&scisig=AMD79ooAAAAAYVx10bmGNrRnU2sdvw7mepye3tpgbRHG&gmla=AJsN-F52UGlKGNR7D_GjW6ssxdyjAnhAUaq5naHJ3K0BmDBXvRjaIIHPp8QaniDB3hq6-8T61qitSvORVmYcmeh_hK0fSnq8gzjRR2xr3ANnycCovrmQKyQ&sciund=2493469662486462863

Full Name

Dr. Aanchal Kakkar

Qualifications

MD (Pathology)

Office Address

1048, Dept. of Pathology, First floor, Teaching Block, AIIMS

Specialty

Head and Neck pathology, Pediatric pathology

Areas of academic and research interest

Head and neck cancer, Pediatric solid tumors, Head and neck infectious and inflammatory diseases

Notable Awards and Honors

• Dr. N. C. Nayak Award for Talented Young Pathologist by Delhi Chapter, Indian Association of Pathologists & Microbiologists, 2016
• Smt. Kunti Devi Mehrotra Award 2015 for best published paper at 64th Annual Conference of Indian Association of Pathologists & Microbiologists (APCON), 2015
• Satya Monga Award for Best Paper in Immunocytochemistry at 45th Annual Conference of Indian Academy of Cytologists, 2015
• Dr. H D Tandon Award for Best Poster at 30th Annual Conference of Delhi Chapter, Indian Association of Pathologists & Microbiologists, 2015
• Hindustan Ciba Geigy Epilepsy Award at 64th Annual National Conference of Neurological Society of India, 2014
• Dr. N C Nayak Medal for Best Senior Resident in Pathology, All India Institute of Medical Sciences, New Delhi, 2013
• Herbert Krause Neuro-Oncology Award  at the 62nd Annual National Conference of Neurological Society of India, 2012
• Dr. V Ramalingaswami Award for Best Paper Presentation at Silver Jubilee Annual Conference of Delhi Chapter, Indian Association of Pathologists & Microbiologists, 2010
• DC IAPM Award for Best Poster Presentation at 24th Annual Conference of Delhi Chapter, Indian Association of Pathologists & Microbiologists, 2009

Books and chapters

• Nayak G, Verma H, Kumar R, Mehta R, Singh N, Thakur K, Sikka K, Kakkar A, Jain D. Tumours of Nose and Paranasal Sinuses In: Verma H, Thakar A (eds). Essentials of Rhinology. Springer Nature, Singapore; 2021 pp157-221
• Chandrashekhara HS, Kakkar AK, Jana M. Tumor and tumor-like conditions. In: Bhalla AS, Jana M (eds). ClinicoRadiological Series: Temporal Bone imaging. Jaypee Brothers Medical Publishers, New Delhi; 2021, pp 243-271   
• Kakkar A, Kumar M, Gupta SD. Molecular Biology of Oral Squamous Cell Carcinoma. In: Bahadur S and Iyer S (eds). Management of Oral Cancers. Springer Nature, Singapore; 2020 pp 23-26
• Bahadur S, Kakkar A, Gupta SD. Potential Malignant Disorders. In: Bahadur S and Iyer S (eds). Management of Oral Cancers. Springer Nature, Singapore; 2020 pp 41-50
• “Head and Neck” South Asia content in Robbins and Cotran Pathologic Basis of Disease 10e South Asia edition 2020
• Suri V, Kakkar A. Animal Models. In: Sanchetee S (ed). A Text Book of Clinical Oncology in the Indian Context. 2019 vol 1. p284-286
• Kakkar A, Sarkar C. Tumors of the Pineal region. In: Sarkar C, Santosh V, Chacko G (eds) Essentials of Diagnostic Surgical Neuropathology. Thieme, New Delhi; 2017 pp 83-90
• Kaur K, Kakkar A, Sarkar C. Embryonal tumors. In: Sarkar C, Santosh V, Chacko G (eds) Essentials of Diagnostic Surgical Neuropathology. Thieme, New Delhi; 2017 pp 91-107
• Kakkar A, Sharma MC. Lymphomas. In: Sarkar C, Santosh V, Chacko G (eds) Essentials of Diagnostic Surgical Neuropathology. Thieme, New Delhi; 2017 pp 145-149
• Purkait S, Kakkar A, Sridhar E. Histiocytic tumors. In: Sarkar C, Santosh V, Chacko G (eds) Essentials of Diagnostic Surgical Neuropathology. Thieme, New Delhi; 2017 pp 151-156
• Kakkar A, Sharma MC. Muscle Biopsy Interpretation In: Arabinda Mukherjee (ed) IAN Textbook of Neurology. Jaypee Brothers Medical Publishers, New Delhi; 2018 pp 702-724
• Kakkar A, Sharma MC. Nerve Biopsy Interpretation In: Arabinda Mukherjee (ed) IAN Textbook of Neurology. Jaypee Brothers Medical Publishers, New Delhi; 2018 pp 725-733

Top Research publications

1. Kakkar A*, Kumar M, Subramanian P, Zubair A, Kumar R, Thakar A, Jain D, Mathur SR, Iyer VK. Utility of the Milan system for Reporting Salivary Gland Cytopathology during Rapid on site evaluation (ROSE) of salivary gland aspirates. Cytopathology 2021 doi: 10.1111/cyt.13038.

2. Thakur R, Thakar A, Malhotra RK, Sharma A, Kakkar A*. Tumor-host interface in oral squamous cell carcinoma: Impact on nodal metastasis and prognosis. Eur Arch Otorhinolaryngol 2021 doi: 10.1007/s00405-021-06756-y.

3. Kaur K, Kakkar A*, Manchanda S, Chatterjee P, Kaur H, Mishra D, Verma H, Kumar R, Sagar P, Jain D, Bhalla AS. Sinonasal IgG4-related disease: a rare and emerging entity broadening the differential diagnosis in the sinonasal universe. Eur Arch Otorhinolaryngol 2021; 278:2883-2890 doi: 10.1007/s00405-020-06564-w.

4. Antony VM, Kakkar A (co-first author), Sikka K, Thakar A, Deo SVS, Bishop JA, Jain D. p16 immunoexpression in sinonasal and nasopharyngeal adenoid cystic carcinomas: A potential pitfall in ruling out HPV-related multiphenotypic sinonasal carcinoma. Histopathology 2020;77:989-993 doi: 10.1111/his.14212.

5. Kakkar A*, Kaur K, Verma A. Pediatric Mediastinal Germ Cell Tumors. Mediastinum. 2019;3:30 doi: 10.21037/med.2019.07.02

6. Kaur K, Kakkar A*, Bhardwaj N, Sakthivel P, Singh CA, Jain D, Mathur SR, Iyer VK, Sood R. Spectrum of cytomorphological features of extranodal NK/ T-cell lymphoma, nasal type. Cytopathology 2019 30:393-401 doi: 10.1111/cyt.12705.

7. Kakkar A, Antony VM, Pramanik R, Sakthivel S, Singh CA, Jain D. SMARCB1 (INI1) -deficient sinonasal carcinoma: A series of thirteen cases with assessment of histological patterns. Human Pathology 2019;83:59-67 doi: 10.1016/j.humpath.2018.08.008.

8. Kakkar A, Guleria P, Madan K, Kumar R, Kumar S, Jain D. Immunohistochemical assessment of BAP1 protein in mucoepidermoid carcinomas. Indian Journal of Otolaryngology and Head & Neck Surgery 2019; 71:33-37. doi: 10.1007/s12070-018-1549-3

9. Kakkar A, Biswas A, Kalyani N, Chatterjee U, Suri V, Sharma MC, Goyal N, Sharma BS, Mallick S, Julka PK, Chinnaswamy G, Arora B, Sridhar E, Chatterjee S, Jalali R, Sarkar C. Intracranial germ cell tumors: A multi-institutional experience from three tertiary care centres in India. Child’s Nervous System 2016;32:2173-2180 doi: 10.1007/s00381-016-3167-2.

10. Kaur K, Kakkar A (co-first author), Kumar A, Mallick S, Julka PK, Gupta D, Suri A, Suri V, Sharma MC, Sarkar C. Integrating molecular subclassification of medulloblastomas into routine clinical practice: a simplified approach. Brain Pathol 2016;26:334–343 doi: 10.1111/bpa.12293.

Ongoing Research Projects

• Molecular characterization of olfactory neuroblastomas for classification into prognostically and therapeutically relevant subgroups (SERB)
• Molecular characterization of salivary gland carcinomas (DBT)
• Evaluation of Machine Learning Techniques including Deep Learning for Identification of Malignancy in Tissue Samples (AIIMS IIT-D collaborative project)

Links

https://scholar.google.com/citations?hl=en&user=KFNUgn8AAAAJ

https://pubmed.ncbi.nlm.nih.gov/?term=aanchal+kakkar&sort=date&size=200

https://www.researchgate.net/profile/Aanchal-Kakkar-3